Importantly, both dementia and T2D are associated with increased mortality risk irrespective of fracture and, by comparing different fracture types/combinations in individuals with the same comorbidity, we were able to deconvolute each specific fracture’s mortality rate to determine whether dementia or T2D act synergistically with the fracture to exacerbate mortality outcomes.ĭata were acquired through queries performed in the TriNetX database (TriNetX, Cambridge, MA, USA) using the Diamond Network on fractures that occurred from January 1, 2010, to Decem(queries were last updated the week of Mathis update was to capture patients with fractures within these time frames whose records were added later). Similarly, T2D has been identified as a fracture risk factor, with insulin treatment status additionally modifying the region-specific fracture. Dementia has been identified as a major risk factor for hip fracture, is associated with increased mortality risk after hip fracture, and is linked to increased postoperative complications following hip fracture repair. This study also examined the extent to which the age-associated comorbidities of dementia and type 2 diabetes (T2D) increase 1-year postfracture mortality rates. We hypothesized that hip fracture would result in greater 1-year mortality rates compared to fractures that did not similarly impact mobility. In addition to simple comparisons of 1-year mortality rates associated with different fracture types and combinations across elderly cohorts, we also used propensity score matching across cohorts to reduce the impact of confounding factors. This study comprehensively compared 1-year mortality rates following fractures of the hip, upper humerus, and lower extremities to determine whether mortality risks differed by fracture type or fracture region in the elderly population as a whole. Since previous studies have suggested that, under specific conditions, fracture location can impact mortality risk, a comparison of hip fractures against other fracture types may help inform postfracture medical care to target high-risk patient populations more specifically. However, hip fracture has rarely been compared against other fracture types in elderly cohorts to understand its specific impact on mortality risk and the unique vulnerabilities associated with it. Recent studies suggest a 17%-25% 1-year mortality rate following hip fracture or its surgical repair in older adults.
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